胎儿大脑体积预测先天性心脏病中的神经发育
Anjali Sadhwani1,2, David Wypij3,4,5, Valerie Rofeberg3
1Department of Psychiatry and Behavioral Sciences (A.S., J.C.), Boston Children's Hospital, MA.
Circulation
|February 10, 2022
概括
在患有先天性心脏病 (CHD) 的儿童中,胎儿大脑体积预测神经发育结果. 胎儿大脑大小与两岁时更好的认知,语言和运动能力有关.
科学领域:
- 儿童神经学
- 胎儿成像
- 遗传性心脏病
背景情况:
- 在患有先天性心脏病 (CHD) 的儿童中,神经发育障碍很普遍.
- 产后因素仅占结果差异的30%,表明产前影响.
- 研究子宫内因素对于了解心血管疾病中的神经发育障碍至关重要.
研究的目的:
- 确定胎儿大脑体积是否预测心脏病发育的结果.
- 探索神经发育障碍的产前原因.
- 确定神经发育风险的潜在成像生物标志物.
主要方法:
- 在隔离心脏病和健康对照的胎儿身上进行了胎儿大脑MRI.
- 使用贝利婴儿和幼儿发育量表 (贝利-III) 和ABAS-3评估了神经发育结果.
- 阶层回归分析了胎儿大脑容量,社会人口统计学和产后因素作为预测因素.
主要成果:
- 尽管胎儿的大脑体积相似,但患有心血管疾病的儿童的贝利-III分数低于对照组.
- 在心脏病组中,更大的胎儿大脑体积与更好的贝利-III和ABAS-3分数相关.
- 胎儿大脑容量独立预测了神经发育结果变异的10-21%
结论:
- 胎儿大脑体积小是心血管疾病2年神经发育结果的重要预测因素.
- 胎儿大脑体积可以作为神经发育风险的成像生物标志物.
- 这些发现支持将胎儿大脑体积纳入风险分层和干预研究.
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