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Updated: Oct 2, 2025

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TDP-43抑制了FTD-ALS基因UNC13A中的神秘外基因包含

X Rosa Ma1, Mercedes Prudencio2,3, Yuka Koike2,3

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|February 24, 2022
PubMed
概括

神经退行性疾病中TDP-43蛋白的损失导致一个神秘的外基因被纳入UNC13AmRNA. 这种拼接事件与增加肌缩侧面硬化 (ALS) 和前性痴呆 (FTD) 风险的遗传变异有关.

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