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Updated: Oct 2, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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过度兴奋的兴奋回路在衰老期间导致睡眠不稳定

Shi-Bin Li1,2, Valentina Martinez Damonte1,2, Chong Chen3,4

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|February 24, 2022
PubMed
概括

由于过度兴奋的低分泌素/氧化素 (Hcrt/OX) 神经元,衰老会影响睡眠质量. 在Hcrt神经元中降低KCNQ2表达导致睡眠碎片化,但KCNQ激活剂可以恢复老鼠的睡眠连续性.

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