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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  2. 研究领域
  3. 生物医学和临床科学
  4. 瘤学和致癌症
  5. 预测和预后标志物
  6. 针对sars-cov-2感染和covid-19疾病的疫苗有效期:系统审查和元回归结果

针对SARS-CoV-2感染和COVID-19疾病的疫苗有效期:系统审查和元回归结果

Daniel R Feikin1, Melissa M Higdon2, Laith J Abu-Raddad3

  • 1Department of Immunisations, Vaccines, and Biologicals, WHO, Geneva, Switzerland.

Lancet (London, England)
|February 24, 2022

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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
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Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
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在PubMed 上查看摘要

概括
此摘要是机器生成的。

虽然COVID-19疫苗对严重疾病的有效性仍然很高,但对感染和症状性疾病的保护在6个月内显著下降. 这凸显了持续评估的必要性,以告知强剂量政策.

科学领域:

  • 免疫学
  • 疫苗学
  • 公共卫生

背景情况:

  • 评估COVID-19疫苗保护的持续时间对于公共卫生政策至关重要,特别是在提升疫苗接种方面.
  • 疫苗的效率下降影响了对额外剂量的时间和必要性的决定.

研究的目的:

  • 系统地审查COVID-19疫苗对各种临床结果的有效性和长寿的证据.
  • 评估疫苗接种后随着时间的推移导致的突破性感染率的变化.

主要方法:

  • 从2021年6月到2021年12月发表的研究和预版的系统审查和元回归.
  • 包括随机控制试验和观察性研究来评估COVID-19疫苗的有效性和有效性.
  • 在接种疫苗后1至6个月内估计疫苗疗效/效率的平均下降.

主要成果:

  • 疫苗对SARS-CoV-2感染的有效性/有效性在接种疫苗后6个月下降了大约21个百分点.
  • 在同一时期,对症状性COVID-19的有效性下降了大约25-32个百分点.
  • 针对严重的COVID-19的保护率较小,约为10个百分点,大多数估计仍在70%以上.

结论:

  • 尽管COVID-19疫苗对严重疾病的有效性在6个月后有所下降,但仍是持久的.

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  • 对感染和症状性疾病的保护更大程度上减弱,这表明补充剂的作用.
  • 为了完善COVID-19疫苗政策,需要进行6个月以上的进一步研究.