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Updated: Oct 2, 2025

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在振荡压力下通过类似电化学压力溶液的表面共振机制提高依赖于频率的溶速率

Kilian Shani Fraysse1, Shane P Meaney2, Will P Gates1

  • 1Institute for Frontier Materials and ARC Centre of Excellence for Electromaterials Science, Deakin University, Waurn Ponds, 3216, Australia.

Journal of the American Chemical Society
|February 28, 2022
PubMed
概括

研究人员发现不同材料在水中的振荡压力极大地增加了化的溶解率. 使用原子力显微镜 (AFM) 观察到的这种新现象表明了表面反应的新可能性.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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