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Updated: Oct 2, 2025

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热蛋白质形揭示了O-GlcNAc-依赖的溶解体

Dustin T King1,2, Jesús E Serrano-Negrón1, Yanping Zhu1,2

  • 1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Journal of the American Chemical Society
|March 1, 2022
PubMed
概括

翻译后的修改会影响蛋白质的稳定性. 一种新的热蛋白质分析方法显示,O-链接的N-乙糖胺 (O-GlcNAc) 经常破坏蛋白质的稳定性,挑战了以前的假设,并显示了双向调节.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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