肺癌的诊断和治疗:一个综述
John A Belperio1, Faisal Shaikh1, Fereidoun G Abtin2
1Division of Pulmonary and Critical Care Medicine, Clinical Immunology, and Allergy, David Geffen School of Medicine, University of California, Los Angeles.
麻症是一种罕见的炎症性疾病,影响多个器官. 渐进的肺肉类增生症可能导致显著的死亡率,需要立即使用葡萄糖皮质体或免疫抑制剂治疗.
科学领域:
- 肺部医学
- 免疫学
- 关节病学
背景情况:
- 石病是一种多系统性炎症性颗粒性疾病,病因不明.
- 全球每10万人中约有2-160人患有这种疾病,肺部受影响很常见.
- 大约10-30%的患者患有进展性肺病.
研究的目的:
- 审查肺癌的临床过程和治疗方法.
- 突出疾病进展和肺高血压的预后影响.
- 讨论目前的治疗策略.
主要方法:
- 关于肉病流行病学,自然史和治疗的文献综述.
- 对进展性肺癌和肺高血压患者的结局分析.
- 综合基于证据的治疗指南
主要成果:
- 肺癌的缓解率有所变化 (10- 82%) 但超过10%的患者出现进展,导致死亡.
- 晚期肺癌与12- 18%的5年死亡率有关.
- 前毛细血管肺高血压影响高达70%的晚期病例,五年死亡率为40%.
结论:
- 五年死亡率为7%,其中肺部感染是主要原因.
- 症状性肺癌症的第一线治疗包括口服葡萄糖皮质类药物,可能包括免疫抑制药物.
- 建议使用固醇酶抑制剂和前列腺素类似剂治疗与沙尔科毒症相关的肺高血压.
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