SARS-CoV-2 Omicron亚系的抗体逃避特性
Sho Iketani1,2, Lihong Liu1, Yicheng Guo1
1Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Nature
|March 3, 2022
概括
欧米克朗变种
科学领域:
- 病毒学
- 免疫学
- 遗传学
背景情况:
- SARS-CoV-2 的 Omicron 变种出现了许多尖端蛋白突变,引发了对抗体逃逸的担忧.
- 亚系BA.1+R346K (BA.1.1) 和BA.2是从Omicron进化而来的,它们在尖端蛋白的改变上有所不同.
研究的目的:
- 用于对Omicron亚系BA.1+R346K和BA.2进行抗原鉴定.
- 评估这些亚系对当前疫苗和单克隆抗体疗法的影响.
主要方法:
- 使用感染个体和接种疫苗的多克隆血清进行抗原鉴定.
- 中和测试用于评估针对SARS-CoV-2变种的抗体活性.
- 对19种中和单克隆抗体对BA2的疗效进行测试.
主要成果:
- 对BA.1+R346K和BA.2的中和活性显著降低,类似于BA.1.
- 在19种测试的单克隆抗体中,BA.2对包括索特罗维马布在内的17种抗体表现出耐药性.
- 只有bebtelovimab对所有测试的Omicron亚系保持了活性.
结论:
- 奥米克朗亚系BA.1+R346K和BA.2在抗原上与野生型SARS-CoV-2不同,可能会降低疫苗的有效性.
- 现有的单克隆抗体疗法可能不涵盖所有Omicron亚系,强调需要更新治疗方法.
- 抗原分离的Omicron亚系的出现需要持续的监测和治疗开发.
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