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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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相关实验视频

Updated: Oct 1, 2025

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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表体转录组工具箱

Sharon Moshitch-Moshkovitz1, Dan Dominissini1, Gideon Rechavi1

  • 1Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel.

Cell
|March 4, 2022
PubMed
概括
此摘要是机器生成的。

传递 RNA (mRNA) 的修改调节了基因表达. 本书回顾了用于检测和研究各种RNA修饰的工具,包括普遍存在的N6-甲基氨酸 (m6A).

关键词:
RNA的修改表体转录组学质谱学转录组

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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
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相关实验视频

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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

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科学领域:

  • 分子生物学
  • 表观遗传学
  • 基因表达的调节

背景情况:

  • 传递 RNA (mRNA) 的修改在调节基因表达方面起着至关重要的作用.
  • 在过去的十年里,成千上万的研究证实了这些变化的意义.
  • 技术的进步使得可以精确地识别和映射整个转录组的RNA修饰.

研究的目的:

  • 为研究RNA修饰提供可用的工具和方法的技术概述.
  • 突出检测和表征各种RNA修饰的方法.
  • 讨论技术的演变,特别是N6-甲基氨酸 (m6A) 和其他修改.

主要方法:

  • 对现有和新兴的RNA修饰检测技术的审查.
  • 对全转录组映射技术的讨论.
  • 对于RNA标记的功能性表征方法.

主要成果:

  • 现在可以准确地识别和绘制越来越多的RNA修饰.
  • 针对像m6A这样的流行变异,已经开发出了特定的方法.
  • 其他RNA修饰的独特特性推动了专门方法的发展.

结论:

  • 目前的技术为RNA修饰的生物学提供了重要的洞察力.
  • 对于研究各种RNA修饰的研究人员来说,有一个多样化的工具包.
  • 这一领域正在不断发展,新的综合分析方法正在出现.