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在心肌细胞内有效的同质导向修复

Yanjiang Zheng1, Nathan J VanDusen2, Catalina E Butler2

  • 1Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China (Y.Z.).

Circulation
|March 7, 2022
PubMed
概括

No abstract available in PubMed .

关键词:
与CRISPR相关的蛋白质9基因组编辑以同质学为导向的dDNA断裂修复肌细胞,心脏

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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