在英国生物库中,SARS-CoV-2 与大脑结构的变化有关
Gwenaëlle Douaud1, Soojin Lee2, Fidel Alfaro-Almagro2
1FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. gwenaelle.douaud@ndcn.ox.ac.uk.
Nature
|March 7, 2022
概括
即使在轻微的病例中,COVID-19 感染也与大脑变化有关,如灰质减少和认知衰退. 这些影响甚至在非住院患者中也被观察到,这表明潜在的长期神经影响.
科学领域:
- 神经学
- 神经成像
- 传染性疾病
背景情况:
- 已知COVID-19会导致大脑异常.
- 在较轻症患者中,SARS-CoV-2 对大脑的影响尚不清楚.
- 研究这些变化可以揭示大脑病理的机制.
研究的目的:
- 与对照组相比,研究SARS-CoV-2感染个体的纵向大脑变化.
- 确定较轻微的COVID-19病例是否表现出可检测的脑部变化.
- 探索COVID-19相关大脑病理的潜在机制.
主要方法:
- 使用了来自英国生物库的785名参与者 (51-81岁) 的感染前和感染后MRI扫描数据.
- 将401例SARS-CoV-2阳性病例与384例对照病例进行比较,诊断和第二次扫描之间的平均时间为141天.
- 分析了灰质厚度,组织对比度,组织损伤标记,整体大脑大小和认知衰退.
主要成果:
- 在SARS-CoV-2病例中,轨道前皮层和副海马圈的灰质减少较大.
- 在与嗅觉皮层相连的区域发现了增加的组织损伤标志物.
- 感染者脑部大小和认知能力下降更大,即使不包括住院患者.
结论:
- 长度大脑变化和认知衰退与SARS-CoV-2感染有关,无论住院状态如何.
- 观察到的变化可能表明神经炎症,嗅觉通路扩散或感觉损失.
- 需要进一步的研究来确定这些大脑变化的可逆性和长期持续性.
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