具有记录孔径的共价有机框架
Zhenjie Mu1, Yuhao Zhu1, Bixiao Li1
1Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, Advanced Technology Research Institute (Jinan), Frontiers Science Center for High Energy Material, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.
Journal of the American Chemical Society
|March 8, 2022
概括
研究人员开发了新的共价有机框架 (COF),具有高达10.0纳米的记录大,均的中介孔. 这些稳定,结晶的材料可以分离像素这样的大生物分子并保护酶.
科学领域:
- 材料科学
- 聚合物化学
- 纳米技术
背景情况:
- 具有可调节孔径的多孔材料对于分子分离和保护至关重要.
- 现有的金属有机框架 (MOF) 和共价有机框架 (COF) 在孔径大小上有局限性,阻碍了大分子的进入.
- 在晶体多孔聚合物中实现均的大质孔仍然是一个重大挑战.
研究的目的:
- 构建新的共价有机框架 (COF) 破纪录,预先设计的中孔孔.
- 克服相互透和结构脆弱的局限性,以创造具有大孔的COF.
- 在涉及大型生物分子的实际应用中证明这些新型COF的实用性.
主要方法:
- 设计和合成具有增强形态刚性,平面性和控制局部极性的新型构件.
- 由此产生的共价有机框架 (COFs) 的结晶性,孔隙性,稳定性和孔隙大小分布的表征.
- 合成的COF用于生物分子分离和酶保护.
主要成果:
- 一系列共价有机框架 (COF) 已成功合成,孔径值在7.7~10.0nm之间,超过了之前的记录.
- 获得的COF具有高结晶性,永久性多孔性,结构稳定性,并显示了叠加性.
- 从原始混合物中成功分离素 (大约7纳米),并保护酸酶免受热诱导的变性.
结论:
- 开发的策略可以构建具有前所未有的大小和均度的共价有机框架 (COF).
- 这些新型COF为先进的分离技术和生物分子稳定提供了重大潜力.
- 这些发现为设计下一代多孔材料为复杂的分子相互作用铺平了道路.
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