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William Shu Ching Ngai1,2, Shaojun Yang1, Xiangmei Zeng1,3

  • 1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Journal of the American Chemical Society
|March 15, 2022
PubMed
概括

研究人员开发了一种生物直角可激活基因编辑器 (BaseBAC),以精确触发炎症性细胞死亡的一种形式. 这种新工具可以在特定的细胞类型中按需启动热,用于先进的生物研究.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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