在中国对野生动物的病毒特征分析揭示了新出现的病原体的频谱
Wan-Ting He1, Xin Hou2, Jin Zhao1
1Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing 210095, China.
Cell
|March 17, 2022
概括
游戏动物携带许多病毒,包括新型病毒,对人类和牲畜构成风险. 这项研究揭示了潜在的跨物种病毒传播,强调野生动物
科学领域:
- 兽医病毒学
- 野生动物疾病生态学
- 基因组学
背景情况:
- 游戏动物是作为食物消费的野生动物,并作为SARS-CoV和SARS-CoV-2等病毒的储存库.
- 了解野生动物中的病毒多样性和传播对于预防动物传染病的出现至关重要.
研究的目的:
- 在中国各地的野生动物中识别和描述病毒.
- 评估病毒从猎物传播到人类和家禽的风险.
- 调查跨物种病毒传播事件.
主要方法:
- 对来自中国18个物种的1941只游戏动物进行了转录基因分析.
- 病毒基因组测序和遗传学分析.
- 新型病毒的鉴定和动物传染潜力的评估.
主要成果:
- 发现了102种感染哺乳动物的病毒,其中65种是新型病毒.
- 21种病毒被归类为可能对人类和家禽造成高风险的病毒.
- (Paguma larvata) 携带了最危险的病毒.
- 证据表明,冠状病毒从蝙蝠传播给和其他跨物种的跳跃 (蝙蝠传播给刺,鸟传播给,狗传播给犬).
- 在和有症状的亚洲中检测到禽流感A型病毒H9N2.
- 发现病毒可能从人类传播给野生动物.
结论:
- 游戏动物是多种病毒的重要储存库,包括新型病毒.
- 鉴定到的病毒多样性和传播模式凸显了野生动物在动物传染病出现中的关键作用.
- 针对野生动物贸易和消费的干预措施对于减轻未来的流行病风险至关重要.
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