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左心室功能和大小的心声测量与事件痴呆症的关联
Wendy Wang1, Michael J Zhang2, Riccardo M Inciardi3
1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis.
JAMA
|March 22, 2022
概括
通过心声学评估的左心房功能受损与患痴呆症的风险较高有关. 然而,在本研究中,LA大小与痴呆风险没有显著的关联.
科学领域:
- 心脏病学
- 神经学
- 老年学
背景情况:
- 以左心房 (LA) 功能障碍和大小变化为特征的心房肌病被认为是缺血性中风的危险因素,独立于心房动 (AF).
- 虽然心房肌病的心电学标志与痴呆相关,但二维心声学 (2DE) 定义的LA功能/大小与痴呆之间的关系尚不清楚.
研究的目的:
- 通过二维心声学 (2DE) 评估的左心房功能和大小与痴呆症发生率之间的关联.
主要方法:
- 使用了来自社区动脉样硬化风险研究 (ARIC) 的数据,这是一个基于社区的前性队列.
- 包括没有患有心房或中风的参与者,基线2DEs (2011-2013),并追踪到2019年12月31日.
- 通过认知评估,住院和死亡证明分析LA功能/大小参数与痴呆发病率之间的关联.
主要成果:
- 在4096名参与者中,在6年的中位数随访期间发现了531例痴呆症.
- 较低的LA储压力,管道压力,收缩压力,空化分数和活性空化分数与痴呆症风险的增加有显著关联 (例如,最低和最高储压力五分位数的HR为1. 98).
- LA大小 (最大和最小体积指数) 与痴呆风险没有显著关联.
结论:
- 左心房功能受损,特别是压力和空气减少,与随后痴呆的风险显著增加有关.
- 用2DE测量的左心房大小与痴呆风险没有显著关联.
- 这些发现表明LA功能的心声测量可以作为痴呆风险的潜在生物标志物.
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