在怀孕期间接种SARS-CoV-2疫苗与怀孕结果的关联
Maria C Magnus1, Anne K Örtqvist2,3, Elisabeth Dahlqwist2
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
JAMA
|March 24, 2022
概括
怀孕期间的COVID-19疫苗接种没有增加过早分娩或死产等不良结果的风险. 这项研究涉及超过157,000名孕妇,其中大多数接种疫苗是在第二和第三个三个月.
科学领域:
- 产科和妇科
- 疫苗学
- 公共卫生
背景情况:
- 关于怀孕期间针对SARS-CoV-2的疫苗安全性的数据有限.
- 评估孕妇COVID-19疫苗接种后的妊娠结果对于公共卫生建议至关重要.
研究的目的:
- 调查怀孕期间的SARS-CoV-2疫苗接种与怀孕不良结果之间的联系.
- 评估早产,死产和其他新生儿并发症的风险.
主要方法:
- 一个回顾性队列研究,使用来自瑞典和挪威的注册数据.
- 包括157,521例单独怀孕,分析了mRNA和病毒载体疫苗暴露的数据.
- 使用统计模型 (Cox回归,物流回归) 和元分析来评估风险.
主要成果:
- 在怀孕期间接种SARS-CoV-2疫苗和早产,死产,怀孕年龄较小,Apgar分数低或新生儿护理入院的风险增加之间没有发现显著的联系.
- 所有评估结果的调整后的危险比率和概率比率接近1,可信度区间包括1.
- 大多数接种发生在第二和第三个季度,主要是mRNA疫苗.
结论:
- 与没有接种疫苗相比,怀孕期间的SARS-CoV-2疫苗接种与这项基于人口的大型研究的不良妊娠结果无关.
- 调查结果表明,COVID-19 疫苗接种对于孕妇来说是安全的,因为它会导致严重的不良结果.
- 这项研究强调了mRNA疫苗在怀孕后期的安全性.
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