螺旋形的古老病毒从棒形的祖先进化为更大的基因组
Fengbin Wang1, Virginija Cvirkaite-Krupovic2, Matthijn Vos3
1Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA.
Cell
|March 24, 2022
概括
对感染古生物的螺旋状病毒的结构研究揭示了它们的螺旋状囊如何扩展. 这项关于Sulfolobus monocaudavirus 1的研究解释了病毒的进化和基因组包装机制.
科学领域:
- 结构生物学
- 病毒学
- 古代生物
背景情况:
- 状或状的病毒感染了各种环境中的古生物.
- 由于它们的复杂形态,对这些多形体的结构研究具有挑战性.
- 在极端,高酸性,高温环境中感染古物宿主.
研究的目的:
- 确定Sulfolobus单病毒1体的原子结构.
- 了解螺旋病毒组件中直径变化的机制.
- 阐明状古病毒的进化起源.
主要方法:
- 病毒囊的原子结构的确定.
- 蛋白质子单元相互作用和组装动态的分析.
- 病毒结构和进化途径的比较分析.
主要成果:
- 体是由具有7链子单元的高度疏水蛋白形成的.
- 准等效相互作用允许螺旋组件的直径发生显著变化.
- 由于保留的子单元相互作用,观察到尾管膨胀的离散步骤.
结论:
- 螺旋组件的直径可以变化,使得更大的基因组包装具有球形.
- 这些发现表明,状病毒是从古老的棒状病毒进化而来的.
- 这项研究提供了关于古老病毒的结构适应性和演变的见解.
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