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Updated: Sep 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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循环二核酸MK-1454的立体选择合成的多种催化反应

Tamas Benkovics1, Feng Peng1, Eric M Phillips1

  • 1Department of Process Research and Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States.

Journal of the American Chemical Society
|March 25, 2022
PubMed
概括

这项研究使用酶催化级联合成MK-1454,一种STING通路激动剂. 这种创新方法结合了新的结合形成策略和酶过程,以实现高效和选择性的构造.

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