人类寿命的脑图
R A I Bethlehem1,2, J Seidlitz3,4,5, S R White6,7
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. rb643@medschl.cam.ac.uk.
Nature
|April 7, 2022
概括
脑图提供了使用10万多个人的MRI数据的脑形态参考标准. 这些图表可以量化大脑发育和人与人之间的差异.
科学领域:
- 神经成像
- 发展神经科学
- 生物统计学
背景情况:
- 神经成像在大脑研究中被广泛使用,但缺乏对个体大脑度量的标准化参考图表.
- 现有的人体成长图为身体发展提供了基准,强调了神经科学中类似工具的需要.
研究的目的:
- 创建一个交互式,开放式的资源 (brainchart.io) 来比较MRI数据中的大脑形态.
- 建立人类一生中大脑结构量化的参考标准.
主要方法:
- 在100多项研究中,从101,457名参与者 (胎儿至100岁) 收集了123,984张MRI扫描.
- 使用百分比比对大脑结构变化的寿命轨迹的量化MRI指标.
- 评估稳定性,对技术变化的强度和百分点的遗传性.
主要成果:
- 发现了新的神经发育里程碑,并证明了随着时间的推移大脑结构的高个体稳定性.
- 大脑图表显示了对研究方法差异的强度.
- 百分比显示遗传性增加,并为神经解剖学变异提供标准化测量.
结论:
- 脑图提供了一个重要的工具,用于对规范性轨迹进行神经成像表型的个体变化量化.
- 这种资源有助于在发育和临床群体中对大脑结构进行标准化比较.
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