粘附GPCRsADGRG2和ADGRG4的绑定激活机制

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Peng Xiao1,2,3, Shengchao Guo3, Xin Wen3

  • 1Department of Clinical Laboratory, The Second Hospital, and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.

Nature
|April 14, 2022
PubMed
概括

粘附G蛋白合受体 (aGPCR) 通过结合的Stachel序列激活,由冷EM结构揭示. 这种机制有助于设计这些古老受体的新激动剂和抗剂.

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