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Updated: Sep 27, 2025

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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粘附性GPCRsADGRD1和ADGRF1的绑定激应的结构基础

Xiangli Qu1,2, Na Qiu1,2, Mu Wang1,3

  • 1CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Nature
|April 14, 2022
PubMed
概括

粘附G蛋白合受体 (aGPCRs) 通过绑定的茎区域激活,而不是裂变. 结构研究显示,ADGRF1中保留的茎- 跨膜相互作用和脂质结合部位,澄清了aGPCR的信号复杂性.

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