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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

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Published on: October 6, 2022

使用抗HIV-1抗体治疗的长期病毒抑制

Christian Gaebler¹, Lilian Nogueira¹, Elina Stoffel^1,2

¹Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

|April 14, 2022

概括

广泛中和抗体在HIV-1治疗中表现有前途,76%的参与者在ART中保持病毒抑制. 抗体治疗也影响了完整的HIV-1储体,这表明未来免疫治疗策略的潜力.

科学领域:

免疫学
病毒学
临床医学

背景情况:

艾滋病毒-1 感染是一个持续的全球健康挑战,需要终身抗逆转录病毒治疗 (ART).
在CD4+T细胞中潜伏的HIV-1前病毒的稳定储存阻止了治愈.
抗HIV-1抗体免疫疗法为感染控制和感染细胞清除提供了潜在的策略.

研究的目的:

评估两种广泛中和抗体组合在携带艾滋病毒的人群中维持病毒抑制的有效性.
评估抗体免疫治疗对潜伏的HIV-1前病毒储存器的影响.
探索抗体血清度与病毒反弹之间的关系.

主要方法:

一项临床研究,在20周内给与艾滋病毒携带或不携带的患者注射7剂双抗体组合.
对参与者的病毒抑制和病毒反弹的监测.
在治疗后分析完整和缺陷的HIV-1前病毒储存库.
后期敏感性分析以确定病毒反弹的预测因素.

主要成果:

76% (13/17) 的参与者在停止ART后至少维持了20周的病毒抑制.
当抗体度降至10μg/ ml以下时发生病毒反弹.
储存器分析显示完整的前病毒储存器发生变化,但缺陷储存器没有显著下降.
两个人保持压抑超过一年.

结论:

结合抗体治疗可以在大多数艾滋病毒感染者中实现持久的病毒抑制.
提供抗体似乎会影响完整的HIV-1储体.
需要进一步进行广泛的研究,以充分阐明抗体免疫治疗对HIV-1储体的影响及其功能治愈的潜力.

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