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Updated: Sep 26, 2025

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基于半素的阿尔基尼化模拟重现了对α-Synuclein的真实后翻译修饰的神经保护作用

Buyan Pan1, Marie Shimogawa1, Jun Zhao2

  • 1Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.

Journal of the American Chemical Society
|April 22, 2022
PubMed
概括

通过改变α- 协核蛋白的聚合,阿尔基尼化是一种蛋白质修饰,可以预防帕金森病. 一种新的方法模仿了这种修饰,为神经保护提供了洞察力,并使这一关键的PTM能够得到更广泛的研究.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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