针对SARS-CoV-2和新兴变种的循环RNA疫苗
Liang Qu1, Zongyi Yi2, Yong Shen2
1Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Cell
|April 23, 2022
概括
一种新型的循环RNA (circRNA) 疫苗表达了SARS-CoV-2尖端蛋白,在动物模型中显示出强大的保护作用. 与mRNA疫苗相比,这种circRNA疫苗的抗原产生和免疫反应优越,对可怕变种提供广泛的保护.
科学领域:
- 病毒学
- 免疫学
- 疫苗开发
背景情况:
- 新出现的SARS-CoV-2变种需要具有更强效和更广泛保护的疫苗.
- 目前的疫苗策略在应对快速变异的病毒株方面面临挑战.
研究的目的:
- 开发和评估针对SARS-CoV-2的新型循环RNA疫苗平台.
- 在临床前模型中评估circRNA疫苗对SARS-CoV-2变种的免疫性和保护性.
主要方法:
- 设计了一种编码SARS-CoV-2尖端蛋白的三元RBD的circRNA疫苗.
- 通过测量小鼠和 rhesus 的中和抗体和T 细胞反应来评估免疫性.
- 对抗SARS-CoV-2疫苗的有效性进行了评估,并与修改后的mRNA疫苗进行了比较.
主要成果:
- 该circRNA疫苗诱导了强大的中和抗体和T细胞反应,从而提供了强大的保护.
- 与mRNA疫苗相比,circRNA疫苗的抗原产量更高且更持久.
- circRNARBD-Delta疫苗提供了对Delta和Omicron变种的保护,并作为有效的助推剂.
结论:
- 循环RNA疫苗为开发有效的SARS-CoV-2疫苗提供了一个有希望的平台.
- circRNA疫苗平台在抗原产生和免疫反应耐久性方面具有优势.
- 一种针对Delta变种的circRNA疫苗显示出针对当前的SARS-CoV-2变种的广泛有效性.
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