大动脉结石患者的维生素K2和D:一项随机双盲临床试验
Axel C P Diederichsen1, Jes S Lindholt2, Sören Möller3
1Department of Cardiology (A.C.P.D., K.A.Ø., M.H.F., S.H.' H.M., J.S.D.), Odense University Hospital, Denmark.
在老年男性中,menaquinone- 7 (MK- 7) 加上维生素D并没有减缓主动脉结石化 (AVC) 的进展. 这项研究发现,MK-7组与安慰剂组之间的AVC得分或相关心血管事件没有显著差异.
科学领域:
- 心脏病学
- 营养科学
- 生物化学
背景情况:
- 维生素K2的一种形式menaquinone-7 (MK-7) 对于抑制动脉化的蛋白质的炭化至关重要.
- 在患有大动脉狭窄症的患者中,MK-7有助于减缓大动脉结石化 (AVC) 的进展.
研究的目的:
- 评估MK-7和维生素D补充剂对老年男性中风进展的影响.
- 评估对主动脉区域的影响,主动脉喷流速度的峰值,以及其他动脉的化.
主要方法:
- 这是一项为期24个月的随机双盲多中心试验,涉及AVC得分高于300AU的男性.
- 参与者每天接受720微克MK-7加25微克维生素D或安慰剂.
- 主要结局:心动脉动脉得分的变化;次要结局:心声测量,手术率,化变化和dp-ucMGP水平.
主要成果:
- 在MK-7和安慰剂组之间,AVC进展没有显著差异 (平均差异:17AU;P=0. 64).
- 在主动脉面积,主动脉喷流速度,主动脉/冠状动脉化,心脏门手术,全因死亡或心血管事件中没有显著差异.
- 与安慰剂相比,MK-7加维生素D显著降低了dp- ucMGP水平 (P< 0. 001).
结论:
- 在老年男性中,MK-7加维生素D补充剂两年没有影响AVC进展,AVC得分> 300AU.
- 虽然MK-7降低了dp-ucMGP,但它没有转化为缓慢化进展的临床益处.
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