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ABO基因型通过调节猪的GalNAc水平来改变肠道微生物群

Hui Yang¹, Jinyuan Wu¹, Xiaochang Huang¹

¹National Key Laboratory for Swine Genetic Improvement and Production Technology, Ministry of Science and Technology of China, Jiangxi Agricultural University, Nanchang, PR China.

|April 27, 2022

概括

宿主基因显著影响肠道微生物组合. 与 ABO 血型相关的特定基因删除会影响肠道中的 Erysipelotrichaceae 细菌的丰富性.

科学领域:

微生物组研究
遗传学和宿主微生物相互作用
肠道健康

背景情况:

肠道微生物组的组成在个体之间有很大差异,与健康有关.
了解宿主-微生物相互作用的遗传基础至关重要,但由于复制困难而具有挑战性.

研究的目的:

研究宿主基因型对遗传多样性的猪群肠道微生物组成的影响.
确定影响特定细菌种群丰富性的遗传因素.

主要方法:

在统一的环境条件下研究了大量的马赛克猪群.
绘制了一种与Erysipelotrichaceae丰富度相关的定量特征位置.
分析了与人类ABO血型相关的N-乙-银胺转移酶中的特定基因缺失.

主要成果:

发现微生物群的组成和特定类型的丰富性是可遗传的.
在N- 乙- 银胺转移酶基因的2. 3kb删除被确定为改变Erysipelotrichaceae丰度的原因.
这种删除,是一种超过350万年的跨物种多态,减少了肠道N-乙-银胺,影响了Erysipelotrichaceae的生长.

结论:

宿主基因型对特定肠道细菌的丰富性有很大影响.
这项研究揭示了将宿主基因变异 (ABO血型相关的缺失) 与肠道微生物组成联系起来的分子机制.
这些发现为探索人类群体中类似宿主遗传效应提供了基础.

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