骨髓形成的不适应性先天免疫训练与炎症并发症有关
Xiaofei Li1, Hui Wang1, Xiang Yu2
1Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
不适应性训练的先天免疫源于骨髓, 导致牙周炎和关节炎等炎症. 这种免疫训练是可转移的,可以针对整体治疗.
科学领域:
- 免疫学
- 血液学
- 炎症研究
背景情况:
- 训练有素的先天免疫 (TII) 增强了免疫反应.
- 骨髓 (BM) 介导的TII涉及造血干细胞和原生细胞 (HSPC) 和髓状细胞.
- 适应不良的TII可能会导致并发性炎症.
研究的目的:
- 使用牙周炎-关节炎轴作为模型,研究BM介导的TII在炎症性并发症中的作用.
- 确定HSPC中牙周炎诱导的训练免疫力是否有助于炎症反应的增加.
- 探索适应性不良的先天免疫训练的治疗向潜力.
主要方法:
- 在小鼠中诱导实验性牙周炎以诱导全身炎症.
- 在HSPC的表观遗传重新连接的分析.
- 骨髓移植实验以评估受过训练的表型的传播能力.
- 在接受炎症关节炎的小鼠中评估炎症反应和疾病严重程度.
- 研究IL-1信号在HSPC培训中的作用.
主要成果:
- 实验性牙周炎诱导了HSPC的表观遗传变化,导致骨髓细胞的产生增加,并增加了炎症潜力.
- 经过牙周炎诱导的训练表型可以通过牙周移植转移.
- 受过培训的BM患者表现出炎症反应增加和炎症性关节炎的恶化.
- 在HSPC中IL-1信号传递对不适应性训练免疫的发展至关重要.
结论:
- 不适应性BM介导的TII有助于炎症性并发症,例如牙周炎-关节炎轴.
- 肌肉形成的先天免疫训练是这些疾病的关键机制.
- 针对不适应的先天免疫训练提供了潜在的整体治疗策略.
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