通过前额外的远程抑制来控制海马体的信号对噪声
Ruchi Malik1, Yi Li1, Selin Schamiloglu1
1Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA.
Cell
|April 29, 2022
概括
前额叶皮层 (PFC) 使用GABAergic投射来控制海马活动,增强空间记忆和对象探索. 这种途径提升了针对目标行为的信息处理.
科学领域:
- 神经科学
- 系统神经科学
- 行为神经科学
背景情况:
- 前额叶皮质 (PFC) 对于上下控制大脑功能至关重要.
- 介导PFC的自上而下的控制途径,特别是对海马的控制途径,尚未完全理解.
研究的目的:
- 识别和描述控制海马信息处理的直接前额道.
- 阐明PFC中介的自上而下的行为控制的神经机制.
主要方法:
- 描述了从PFC到海马的单突触长距离GABAergic投射.
- 在体内刺激前额-海马体GABAergic投射.
- 测量海马活动和空间信息编码.
主要成果:
- 前额突起优先抑制海马体中的血管活性肠道多 (VIP) 表达内神经元.
- 刺激增加了海马体前进抑制和降低了海马体的整体活动.
- 提高海马体对象位置记忆和对象诱导的空间信息的信号噪声比.
结论:
- 通过GABAergic投射确定了一条从PFC到海马的新型上下路径.
- 这种途径通过抑制消毒性VIP内部神经元来调节海马的微电路.
- 证明这种PFC-海马回路增强了空间信息处理,并促进了探索行为.
相关概念视频
Sound Waves: Interference
4.2K
Sound waves can be modeled either as longitudinal waves, wherein the molecules of the medium oscillate around an equilibrium position, or as pressure waves. When two identical waves from the same source superimpose on each other, the combination of two crests or two troughs results in amplitude reinforcement known as constructive interference. If two identical waves, that are initially in phase, become out of phase because of different path lengths, the combination of crests with troughs...
4.2K
Echo
1.2K
The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case,...
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case,...
1.2K
Parallel Resonance
856
The parallel RLC circuit is an arrangement where the resistor (R), inductor (L), and capacitor (C) are all connected to the same nodes and, as a result, share the same voltage across them. The parallel RLC circuit is analyzed in terms of admittance (Y), which reflects the ease with which current can flow. The admittance is given by:
856


