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间歇性PI3Kδ抑制维持抗瘤免疫力并抑制irAEs

Simon Eschweiler1, Ciro Ramírez-Suástegui1, Yingcong Li1,2

  • 1La Jolla Institute for Immunology, La Jolla, CA, USA.

Nature
|May 4, 2022
PubMed
概括

通过减少调节性T细胞和增强抗瘤免疫力,酸3-激酶δ (PI3Kδ) 抑制剂在头癌中表现有前途. 然而,毒性限制了目前的剂量,表明需要替代方案.

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