在第三剂 SARS-CoV-2 mRNA 疫苗后有效召回 Omicron 反应性 B 细胞记忆
Rishi R Goel1, Mark M Painter2, Kendall A Lundgreen3
1Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Immune Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|May 6, 2022
概括
接种SARS-CoV-2 mRNA疫苗会产生持久的抗体和记忆B细胞反应. 第三剂可增强免疫力,但高抗体水平可能会缓解进一步增强的反应.
科学领域:
- 免疫学
- 病毒学
- 疫苗学
背景情况:
- 了解SARS-CoV-2 mRNA疫苗接种后免疫反应的长寿和质量对于公共健康至关重要.
- 在初次接种疫苗和强剂后,对抗体和B细胞记忆动态的长度数据对于评估疫苗随时间推移的有效性至关重要.
研究的目的:
- 在初级二剂SARS-CoV-2 mRNA疫苗接种和随后的第三剂疫苗接种后,对抗体和B细胞记忆反应进行纵向评估.
- 评估疫苗诱导的免疫记忆的耐用性,质量和变异结合能力.
主要方法:
- 对抗体标位和记忆B细胞群的纵向采样和分析.
- 对记忆B细胞与SARS-CoV-2变种 (阿尔法,贝塔,德尔塔,奥米克朗) 的结合进行评估.
- 在接种第三剂疫苗后评估B细胞再激活和中和抗体标位.
主要成果:
- 在接种疫苗后6至9个月,抗体水平稳定,抗体质量在9个月后得到改善.
- 尖端和RBD特异性B细胞保持持久性,其中很大一部分结合了多种SARS-CoV-2变体.
- 第三剂疫苗有效地重新激活了与中和抗体增加相关的Omicron结合记忆B细胞.
- 增强前抗体标位与抗体增强的大小相反相关.
结论:
- mRNA 疫苗注射会诱导对 SARS-CoV-2 的持续性 humoral 和细胞免疫力.
- 记忆B细胞表现出广泛的变体结合能力,并通过随后的剂量有效地增强.
- 高水平的抗体可能会对额外的疫苗剂量产生反应,影响整体保护.
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