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淋巴结殖民诱导瘤免疫耐受性促进远程转移

Nathan E Reticker-Flynn¹, Weiruo Zhang², Julia A Belk¹

¹Department of Pathology, Stanford University, Stanford, CA 94305, USA.

|May 7, 2022

概括

在固体瘤中,淋巴结转移积极促进远程扩散. 淋巴结中的瘤逃避免疫反应并诱导耐受性,促进进一步的殖民和全身性疾病的进展.

科学领域:

癌症学
免疫学
癌症转移

背景情况:

淋巴结的参与是固体恶性瘤的关键预后因素,表明远程转移的潜力.
在形成远程转移方面,LN转移的作用尚不清楚.

研究的目的:

调查瘤扩散到LN的机制.
确定LN殖民是否影响到远处组织的转移.

主要方法:

开发LN转移的突发性黑色素瘤小鼠模型.
对瘤内在干扰素反应方案的分析.
在LN中评估免疫逃避和殖民动态.

主要成果:

由表观遗传调节的瘤内在干扰素反应增强了LN转移潜力.
这种反应促进了自然杀手 (NK) 细胞的逃避,并促进了LN殖民.
LN转移抵抗T细胞间接杀死,诱导调节性T细胞,并建立免疫耐受性,促进远程殖民.

结论:

通过免疫规避和耐受性诱导,LN转移积极促进远程传播.
这种机制在不同类型和种类的癌症中保持一致.
了解这一过程为治疗转移性疾病提供了潜在的治疗目标.

关键词:

其他产品标签:MHC-I NK 细胞其他类型其他干扰素淋巴结发生转移监管T细胞耐受性

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