嗅觉感觉经验通过神经元IGF1调节质生成
Pengxiang Chen1,2,3,4, Wei Wang1,2,3, Rui Liu1,2,3
1Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Nature
|May 11, 2022
概括
嗅觉刺激可以直接影响大脑瘤的发展. 嗅觉激活特定的大脑细胞,释放促进小鼠质瘤形成的生长因子.
科学领域:
- 神经科学
- 癌症学
- 感官生物学
背景情况:
- 感官输入对于生存至关重要,
- 恶性质瘤与神经元相互作用,
研究的目的:
- 调查外部感官刺激,特别是嗅觉,是否会直接影响恶性质瘤的发展.
- 阐明连接感官输入到质生成的基本机制.
主要方法:
- 使用原生小鼠模型的成年质细胞生成源于寡细胞前体细胞 (OPC).
- 操纵嗅觉受体神经元 (ORN) 活动,并执行基因淘汰 (中/细胞中的Igf1,OPC中的IGF1受体).
主要成果:
- 质瘤主要发生在嗅觉球,
- 嗅觉刺激导致中和形细胞释放胰岛素样生长因子1 (IGF1).
- 消除Igf1或其受体显著抑制了质瘤的发展,将嗅觉与质瘤发生联系起来.
结论:
- 嗅觉通过激活特定的神经回路直接调节质生成.
- 这项研究通过嗅觉系统建立了感官体验与脑瘤形成之间的新联系.
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