父母染色体对雄性基因----雄性基因基因基因小鼠中基因基因基因小鼠中的空间特异性的影响
Nature
|March 1, 1987
概括
母亲和父亲的基因组对于小鼠胚胎发育至关重要. 化学胚胎表现出细胞的空间分离,但充分发育需要在同一细胞内的父母基因组.
科学领域:
- 发展生物学 发展生物学
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 适当的小鼠胚胎发育需要母体和父体基因组.
- 安德罗基因和基因胚胎表现出不同的表型,突出了互补的基因组信息.
- 结合雄性基因和基因细胞的奇米拉为研究父母基因组功能提供了一个模型.
研究的目的:
- 为了研究在老鼠嵌合体中结合androgenetic和parthenogenetic细胞的功能后果.
- 为了确定来自不同父母来源的细胞的空间分布和发育贡献.
- 了解共同定位的父母基因组对于完整的胚胎发育的必要性.
主要方法:
- 构建雄性基因 - 基因基因的仿真小鼠胚胎.
- 对胚胎组织,热囊细胞和黄囊细胞分布的分析.
- 测定化母胎儿的发育进展和生存能力.
主要成果:
- 部分遗传细胞主要存在于胚胎本身.
- 雄激素细胞在很大程度上形成了 trofhoblast.
- 黄囊中含有这两种细胞类型的混合物.
- 化学胎儿没有发展到期,表明功能补充不完整.
结论:
- 嵌合体中的父母基因组表达导致细胞系的空间分离.
- 没有达到期限表明,父母基因组在相同的细胞内共同定位对于完整的小鼠发育至关重要.
- 超越基因组印记的发育控制可能依赖于单个细胞中两组染色体的存在.
相关概念视频
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