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Updated: Sep 22, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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通过IscB-ωRNA引导DNA裂变的结构基础和与Cas9的机制比较

Gabriel Schuler1, Chunyi Hu1, Ailong Ke1

  • 1Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA.

Science (New York, N.Y.)
|May 26, 2022
PubMed
概括

像Cas9这样的2类CRISPR受体可能是从转子核酶进化而来的. IscB-ωRNA结构与Cas9有相似之处,解释了DNA裂变机制和ωRNA

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