局部障碍构成了宿主和微生物群之间的系统通信
Qiuhe Lu1, Thaddeus S Stappenbeck1
1Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
概括
了解宿主微生物群对于健康至关重要. 需要进行功能性研究来识别关键的微生物及其化学信号, 以供未来的治疗应用.
科学领域:
- 微生物学
- 主体与微生物的相互作用
- 系统生物学
背景情况:
- 宿主微生物群,一个充满活力的微生物群,对宿主健康至关重要.
- 微生物与宿主之间的交流是通过通过生理障碍分泌的分子进行的.
- 欧米克的方法揭示了许多微生物与宿主过程和疾病的关联.
研究的目的:
- 突显微生物群研究中的转化差距.
- 确定关键微生物,菌株变异和微生物代谢物的知识缺口.
- 强调了解微生物群与宿主相互作用的功能方法的必要性.
主要方法:
- 审查现有的"omics"数据和文献.
- 讨论功能性微生物群研究的挑战.
- 探索王国间的相互作用 (细菌,菌体,原生动物,真菌).
主要成果:
- 尽管取得了进展,但基于微生物群的治疗方法的转化成功仍然有限.
- 关于特定的微生物作用,菌株的重要性和代谢物功能存在重大知识缺口.
- 微生物之间的相互作用增加了微生物群与宿主之间的复杂性.
结论:
- 功能性研究对于促进微生物群研究至关重要.
- 了解微生物群的化学产量和菌株水平的变化至关重要.
- 释放微生物群的治疗潜力需要克服实验挑战.
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