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Updated: Aug 17, 2026

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons
15:01

Quantitative, Real-time Analysis of Base Excision Repair Activity in Cell Lysates Utilizing Lesion-specific Molecular Beacons

Published on: August 6, 2012

通过核糖酶A裂变在莱什-尼汉位点的突变的识别和定位

R A Gibbs, C T Caskey

    Science (New York, N.Y.)
    |April 17, 1987
    PubMed
    概括

    这项研究引入了一种用于检测单基DNA变化的新方法,这对于诊断莱什-尼汉综合征等遗传疾病至关重要. 核糖核酶A分裂试验成功地在一半的测试患者中发现了素基转移酶 (HPRT) 的突变.

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