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兰氏生物合成中的部分改性介质改变了兰氏合成酶的结构和动态

Yeganeh Habibi1, Nuwani W Weerasinghe1, Kevin A Uggowitzer1

  • 1Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.

Journal of the American Chemical Society
|June 1, 2022
PubMed
概括

第二类兰氏合成酶 (LanM酶) 修改前体来制造复杂的天然产品. 这项研究揭示了前体修饰如何系统地改变HalM2酶的结构和动态,确保高保真生物合成.

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