一种类似于组织的神经递质传感器用于大脑和肠道
Jinxing Li1,2, Yuxin Liu3, Lei Yuan4
1Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
Nature
|June 1, 2022
概括
研究人员开发了一种灵活的生物传感器NeuroString, 通过追踪动态器官中的神经化学物质来帮助理解神经功能和诊断疾病.
科学领域:
- 神经科学
- 生物工程
- 材料科学
背景情况:
- 神经递质对包括肠道在内的中枢和外围神经系统的神经电路调节至关重要.
- 实时监测神经递质对于理解神经功能和疾病诊断至关重要.
- 目前用于神经递质监测的体内生物电子工具尚未得到充分发展,特别是对于肠道神经系统等柔软,动态的器官.
研究的目的:
- 推出一种新的,模仿组织的,可伸缩的生物传感器,用于体内神经递质监测.
- 克服当前生物电子工具在评估软和移动器官方面的局限性.
- 在复杂的生物环境中实现慢性,实时,多通道和多重传递器传感.
主要方法:
- 使用金属复合物聚合物的激光图案制成弹性体内的石墨烯/纳米粒子网络来制造NeuroString传感器.
- 在实体内长期植入和实时监测行为小鼠的大脑中的单胺动力学.
- 在体内测量肠道中的血清激素动态,而不会引起刺激或扰乱自然运动.
主要成果:
- 在老鼠大脑中表现出慢性实时,多通道和多重氨基胺传感.
- 在肠道中成功测量血清激素的动态, 保持器官功能和运动.
- 在复杂,动态的生物组织中开发了弹性和可调整的生物传感接口.
结论:
- 它提供了一个先进的生物电子工具,用于实时监测神经递质.
- 这种传感器克服了与监测柔软,活跃的器官相关的挑战.
- 这项技术有很大的潜力研究大脑与肠道之间的沟通,肠道微生物组的相互作用,以及其他软体器官的生物分子传感.
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