组合抗艾滋病毒抗体提供持续的病毒抑制
Michael C Sneller1, Jana Blazkova1, J Shawn Justement1
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Nature
|June 1, 2022
概括
长期作用的广泛中和单克隆抗体,3BNC117和10-1074对长期抑制人类免疫缺陷病毒 (HIV) 有希望. 这种艾滋病毒治疗为每日抗逆转录病毒治疗提供了潜在的替代方案.
科学领域:
- 免疫学
- 病毒学
- 临床医学
背景情况:
- 抗逆转录病毒治疗 (ART) 有效抑制人类免疫缺陷病毒 (HIV),但需要终身每日坚持治疗.
- 完全根除艾滋病毒仍然是难以捉摸的,需要开发其他长效的抗病毒策略.
- 广泛中和单克隆抗体 (bNAbs) 的被动转移是一种新的治疗方法.
研究的目的:
- 评估两种特定于HIV的bNAbs,3BNC117和10-1074的长期病毒抑制的安全性和有效性.
- 评估bNAb治疗作为每日ART替代剂的潜力.
- 为下一代基于抗体的长效艾滋病毒疗法的未来临床试验提供信息.
主要方法:
- 进行了一项由两个组成部分组成的临床试验:一项随机,双盲,安慰剂对照试验,参与者在急性/早期艾滋病毒感染期间开始接受ART治疗,另一项是对未接受ART治疗的病毒控制患者进行的开放性试验.
- 参与者在24周内接受了最多8次bNAb组合 (3BNC117和10-1074).
- 在分析性治疗中断后对病毒载量进行监测,以评估持续的抑制.
主要成果:
- 治疗bNAb组合的耐受性很好,没有与输液相关的严重不良事件.
- 在没有先前存在抗体抵抗性HIV的参与者中,bNAb组合维持了治疗中断后长达43周的完全血病毒抑制,超过了安慰剂.
- 在没有接受ART的参与者中观察到类似的强效HIV抑制,这些参与者具有敏感的基线病毒.
结论:
- 结合广泛中和单克隆抗体的治疗可以在艾滋病毒患者中实现长期的病毒抑制,而不需要每天服用ART.
- 这项研究表明bNAb输液作为一种可行的长效HIV治疗策略.
- 这些发现为未来研究基于抗体的先进HIV干预的临床试验设计提供了宝贵的见解.
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