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Updated: Sep 21, 2025

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
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由环烯反应剂启用的正交N-蛋白特异蛋白修饰平台

Alena Istrate1, Michael B Geeson1, Claudio D Navo2

  • 1Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.

Journal of the American Chemical Society
|June 6, 2022
PubMed
概括

新的环烯 (CPO) 试剂可以选择性地修改蛋白质上的N端囊残留物. 这种蛋白质结合策略使精确的生物结合物构造和治疗开发成为可能.

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