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Updated: Sep 20, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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在细菌中调解向蛋白质降解的BacPROTACs

Francesca E Morreale1, Stefan Kleine2, Julia Leodolter1

  • 1Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.

Cell
|June 6, 2022
PubMed
概括

研究人员开发了向细菌蛋白质分解的仿真体 (BacPROTACs) 来降解细菌蛋白质. 这项新技术激活了针对蛋白质破坏的ClpC:ClpP蛋白酶,为抗生素发现提供了新的途径.

关键词:
AAA蛋白质酶抗菌药物细菌的PROTACs有针对性的蛋白质降解

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