在接种疫苗后,强烈的交叉反应性抗体
Rungtiwa Nutalai1, Daming Zhou2, Aekkachai Tuekprakhon1
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Cell
|June 6, 2022
概括
新的Omicron亚型如BA.2由于更高的ACE2亲和力和减少的疫苗中和性,显示出更高的传染性. 针对SARS-CoV-2受体结合域的强有力的抗体对于对抗这些不断演变的变体至关重要.
科学领域:
- 病毒学
- 免疫学
- 结构生物学
背景情况:
- 在全球范围内,高传染性Omicron型的SARS-CoV-2变种占据主导地位,因此需要了解它们的免疫规避特性.
- BA.1,BA.1,BA.2等亚系表现出影响病毒传播和中和的独特特征.
研究的目的:
- 将中和能力与Omicron BA.1,BA.1,BA.2亚系进行比较.
- 分析SARS-CoV-2变种的抗体识别和中和的结构基础.
主要方法:
- 通过疫苗血清和单克隆抗体 (mAbs) 的中和比较分析.
- 对27个强受体结合域 (RBD) 结合mAbs的结构和功能分析.
- 对不同Omicron亚系的ACE2结合亲和度的评估.
主要成果:
- 与BA.1相比,BA.2具有略高的ACE2亲和力,并且通过疫苗血清中和性降低.
- 在BA.2和BA.1.1中的特定突变显著降低了像Vir-S309这样的治疗抗体的中和.
- 隔离的mAbs显示出早期SARS-CoV-2菌株的强烈中和和广泛的反应性,与右肩抗体的显著流行.
结论:
- 了解Omicron亚型的中和情况对于开发有效的对策至关重要.
- 抗体反应,特别是针对保存的RBD表位的抗体,显示出对SARS-CoV-2变种的广泛保护的潜力.
- 抗体的体质成熟在优化抗病毒突变的效力方面发挥着关键作用.
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