怀孕可以防止细胞内感染的抗体
John J Erickson1,2, Stephanie Archer-Hartmann3, Alexander E Yarawsky4
1Department of Pediatrics, Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Nature
|June 8, 2022
概括
怀孕改变了母亲的抗体,使新生儿能够抵抗细胞内感染,比如Listeria monocytogenes 这种适应通过脱乙基化IgG和CD22受体增强新生儿免疫力.
科学领域:
- 免疫学
- 微生物学
- 新生儿健康
背景情况:
- 适应性免疫传统上将细胞外作用分配给抗体,细胞内作用分配给T细胞.
- 新生儿对细胞内病原体的敏感性与对母体抗体的依赖有关.
- 怀孕涉及免疫适应影响母亲和胎儿的健康.
研究的目的:
- 调查孕产妇诱导的抗体修饰,从而提供对细胞内病原体的保护.
- 阐明母体抗体保护新生儿免受细胞内感染的机制.
- 了解抗体脱和特定受体在新生儿免疫中的作用.
主要方法:
- 使用Listeria monocytogenes感染的小鼠模型.
- 从孕妇和处女小鼠转移的被动抗体.
- 研究了酸乙酶和CD22在抗体功能中的作用.
- 评估B细胞IL-10的产生和新生儿感染的易感性.
主要成果:
- 在新生小鼠中,孕期诱导的母体IgG修饰会对Listeria monocytogenes产生保护作用.
- 用酸乙酶去乙化IgG对于获得保护功能至关重要.
- 通过CD22受体进行脱乙基化IgG介导的保护,抑制B细胞IL-10的产生.
- 孕产妇的B细胞对于产生抗体至关重要,但对于获得保护功能至关重要.
结论:
- 孕期诱导的抗体脱乙烯化提供了对细胞内病原体的保护.
- 这种机制通过调节B细胞反应来增强新生儿的免疫力.
- 孕产妇与胎儿的双体作为一个统一的免疫单元,
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