人类冠状病毒CCoV-HuPn-2018尖端糖蛋白的结构,受体识别和抗原性

M Alejandra Tortorici1, Alexandra C Walls2, Anshu Joshi1

  • 1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Cell
|June 14, 2022
PubMed
概括

在人类中发现了一种新型犬类冠状病毒 (CCoV-HuPn-2018),突显了跨物种病毒传播的增加. 研究人员阐明了它的尖端蛋白结构,并确定了aminopeptidase N (APN) 作为其入口受体,为治疗开发铺平了道路.

相关概念视频

Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.5K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
63.5K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
13.2K