黑死病的源头在14世纪的欧亚中部
Maria A Spyrou1,2,3, Lyazzat Musralina4,5,6,7, Guido A Gnecchi Ruscone4,5
1Institute for Archaeological Sciences, Eberhard Karls University of Tübingen, Tübingen, Germany. maria.spyrou@ifu.uni-tuebingen.de.
Nature
|June 15, 2022
概括
黑死病可能起源于14世纪的吉尔吉斯斯坦. 古代DNA证实瘟疫细菌Yersinia pestis是造成这一早期流行病的原因,
科学领域:
- 基因组学
- 考古学
- 流行病学
背景情况:
- 黑死病 (1346-1353年) 的起源仍有争议,在吉尔吉斯斯坦的伊西克库尔湖附近有潜在的证据.
- 1338-1339年的墓碑铭文表明这些地方发生了瘟疫事件.
研究的目的:
- 为了调查黑死病的起源.
- 分析可能与1338-1339年疫情有关的人的古老DNA.
- 确定疫情早期的Yersinia pestis的作用.
主要方法:
- 在吉尔吉斯斯坦的卡拉-吉加奇和布拉纳墓地挖掘了七个人.
- 古代DNA提取和测序以重建Yersinia pestis的基因组.
- 与来自天山地区的现代菌株进行基因组比较分析.
主要成果:
- 古老的基因组数据证实了Yersinia pestis的参与
- 两个重建的基因组代表了一个单一的菌株,被确定为主要多样化事件的最近共同祖先.
- 这种祖先可以追溯到14世纪上半叶,
结论:
- 这项研究为第二次瘟疫的中欧亚起源提供了有力的证据.
- 发现的Yersinia pestis菌株与黑死病的最初出现有关.
- 这项研究综合了考古,历史和基因组数据,
更多相关视频
07:21Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
Published on: August 25, 2018
13.0K
09:02An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
20.0K
相关概念视频
Infection
8.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.7K
Pulmonary Tuberculosis III
437
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
437
Causality in Epidemiology
784
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
784
Pulmonary Tuberculosis I
320
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
320
Pulmonary Tuberculosis II
337
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
337
Endocarditis II: Clinical Features of Infective Endocarditis
24
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
24
