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乳腺癌的转移在睡眠期间加快

Zoi Diamantopoulou¹, Francesc Castro-Giner¹, Fabienne Dominique Schwab^2,3

¹Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

|June 22, 2022

概括

大多数通过循环瘤细胞 (CTC) 传播的癌症发生在睡眠期间. 这些休息阶段的CTC容易转移,与活跃期产生的不同,提供了新的治疗时间策略.

科学领域:

癌症学
时间生物学
癌症转移

背景情况:

癌症的转移是通过循环瘤细胞 (CTC) 发生的.
转基因细胞发生的时间和转基因潜力在很大程度上是未知的.
目前的假设表明由于机械应力而导致的CTC脱落或脱落.

研究的目的:

研究循环瘤细胞 (CTC) 生成的时间动态.
确定在特定活动或休息阶段产生的CTC是否具有不同的转移潜力.
阐明CTC生成和转移能力的潜在机制和荷尔蒙影响.

主要方法:

在乳腺癌患者和小鼠模型中观察CTC生成模式.
单细胞RNA测序分析
调查昼夜节律激素 (美拉,,皮质糖类) 和胰岛素的作用.

主要成果:

大多数自发性CTC输血事件发生在睡眠 (休息阶段).
在休息阶段产生的CTC具有高转移潜力,而活跃阶段的CTC则没有.
在休息阶段的线粒基因升级与转移能力相关.
循环激素和胰岛素以时间依赖的方式影响CTC生成和扩散.

结论:

自发生成的转移性CTC集中在休息阶段,而不是连续的.
这种时间模式为控制时间的癌症检查和治疗提供了新的基础.
了解对CTCs的昼夜影响为新型抗转移策略开辟了道路.

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