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Updated: Sep 6, 2025

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
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小分子激活OGG1通过获得新的功能增加了氧化DNA损伤的修复

Maurice Michel1, Carlos Benítez-Buelga1,2, Patricia A Calvo3

  • 1Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.

Science (New York, N.Y.)
|June 23, 2022
PubMed
概括

一个新的小分子TH10785增强了8-oxoguanine DNA糖酶1 (OGG1) 的活性,改善了氧化DNA损伤的修复. 这一发现为治疗疾病和衰老提供了潜在的治疗策略.

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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