肠道病毒在唾液腺复制并通过唾液感染
S Ghosh1, M Kumar1, M Santiana1
1Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nature
|June 29, 2022
概括
肠道病毒感染唾液腺,通过唾液复制和传播. 这一发现揭示了一种超出便口腔的新传播途径,影响了母婴传播和卫生策略.
科学领域:
- 病毒学
- 胃肠病学
- 免疫学
背景情况:
- 肠道病毒传统上通过便口腔传播.
- 唾液腺 (SG) 不被认为是肠道病毒复制的主要部位.
- 一些病毒,如狂犬病,感染SG并通过唾液传播.
研究的目的:
- 调查肠道病毒是否在唾液腺中感染和复制.
- 确定肠道病毒的新传播途径.
- 探索唾液腺感染对疾病传播和控制的影响.
主要方法:
- 用肠道病毒感染SG衍生的球体和细胞系.
- 在SG和肠道中定量病毒标位.
- 将病毒释放到唾液中的分析.
- 通过唾液和牛奶对婴儿传播的调查.
主要成果:
- 肠道病毒有效且持续地感染唾液腺.
- SGs中的病毒标位与肠道标位相似.
- 肠道病毒释放到唾液中, 建立新的传播途径.
- 婴儿的唾液可以传递肠道病毒到母亲的乳腺, 绕过肠-乳腺轴.
结论:
- 唾液腺是肠道病毒的重要复制部位.
- 唾液是肠道病毒传播的新重要途径.
- 这些发现需要修订卫生和预防策略,以减轻病毒通过唾液传播.
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