软,可生物吸收的冷却器用于外围神经的可逆导电阻
Jonathan T Reeder1,2,3, Zhaoqian Xie4,5, Quansan Yang3,6
1Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Science (New York, N.Y.)
|June 30, 2022
概括
新的柔软,可生物吸收的微流体装置提供针对性的神经冷却来缓解疼痛, 可能取代阿片类药物. 这些可植入的设备在使用后溶解,不需要进行手术切除,并提供按需的止痛.
科学领域:
- 生物医学工程
- 材料科学
- 神经科学
背景情况:
- 虽然阿片类药物通常用于缓解疼痛,
- 外围神经阻断提供了另一种疼痛管理策略.
- 目前的神经阻断技术面临的局限性包括侵入性和缺乏可逆性.
研究的目的:
- 开发和评估新的柔软的,可生物吸收的微流体装置,用于针对性的外围神经冷却.
- 评估使用这些设备以应要求,可逆性缓解疼痛的可行性.
- 提供对阿片类止痛药的微创替代品.
主要方法:
- 使用生物相容,水溶性材料制造柔软的微流体器件.
- 在老鼠模型中植入针对外围神经冷却的装置.
- 实时温度反控制用于精确的冷却.
- 在神经病痛模型中评估止痛效应.
主要成果:
- 这些装置能够精确且快速地冷却外围神经.
- 在神经性疼痛的小鼠模型中证明了可逆性止痛.
- 这些装置的生物吸收性消除了外科切除的必要性.
- 多周的体内试验证实了设备的安全性和有效性.
结论:
- 软,可生物吸收的微流体装置代表了针对神经冷却的有前途技术.
- 这种方法提供了一种极少侵入性的,按需的,并可能节省阿片类药物的疼痛管理方法.
- 进一步的发展可能会导致慢性和急性疼痛的新治疗策略.
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