在工程功能材料的超分子聚-聚网络中分子相互作用的作用
Yiyuan Han1, René P M Lafleur1, Jiajing Zhou1,2
1Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Journal of the American Chemical Society
|July 1, 2022
概括
我们开发了一种简单的方法, 这些材料具有可调节的特性和增强的药物输送,为纳米医学提供了多功能平台.
科学领域:
- 生物材料科学
- 纳米医学
- 聚合物化学
背景情况:
- 聚的超分子组合对于开发用于药物输送和纳米医学的先进生物材料至关重要.
- 目前的方法通常需要复杂的化学物质,限制了基于多种的材料的快速合成和研究.
研究的目的:
- 开发一个多功能和简单的平台,使用多制造基于多的生物材料.
- 研究聚聚网络中的相互作用及其对材料特性的影响.
- 评估这些生物材料在药物输送应用中的有效性.
主要方法:
- 使用多来与各种多侧组产生协同交联相互作用.
- 使用结合亲和力,热力学和分子对接来分析多-多相互作用.
- 使用模板介导策略制造的独立聚聚囊.
- 评估囊特性 (外厚度,透性) 和药物递送效率 (多克索鲁比辛的吸收和细胞死亡).
主要成果:
- 与其他氨基酸相比,多与正电荷的多和多产生更强的相互作用.
- 根据使用的同聚,囊的特性有所不同,充电的多聚形成更厚的,不太透的外.
- 聚氨酸 - 酸囊显示细胞透,内体逃逸和多克索鲁素输送 (2. 5 倍更高的光).
- 与聚氨酸酸囊相比,聚氨酸酸囊在体外导致细胞死亡显著增加.
结论:
- 使用多的多功能策略可以快速创建各种基于多的生物材料.
- 这些材料的调节性,由特定的多-多相互作用驱动,适合各种应用.
- 聚聚囊有望增强药物输送,特别是在需要细胞透和内体逃逸的应用中.
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